Table IV.
Tear Fluid Concentration of Forskolin After Administration of Formulation
| Time (h) | Forskolin concentration in tear fluid (µg/µl) | |||
|---|---|---|---|---|
| Forskolin suspension | PL18FN | AA03FN | A3P4FN | |
| 0 | 0 | 0 | 0 | 0 |
| 0.017 | 7.754 ± 0.18 | 3.112 ± 0.26 | 2.935 ± 0.22 | 2.112 ± 0.24 |
| 0.083 | 0.522 ± 0.05 | 3.035 ± 0.12 | 2.435 ± 0.25 | 2.012 ± 0.18 |
| 0.5 | – | 2.567 ± 0.15 | 2.102 ± 0.18 | 1.829 ± 0.16 |
| 1 | – | 2.324 ± 0.14 | 2.042 ± 0.24 | 1.551 ± 0.25 |
| 2 | – | 2.423 ± 0.16 | 1.853 ± 0.12 | 1.531 ± 0.21 |
| 3 | – | 0.172 ± 0.08 | 1.582 ± 0.14 | 1.411 ± 0.15 |
| 4 | – | – | 0.056 ± 0.05 | 1.513 ± 0.14 |
| 5 | – | – | – | 1.603 ± 0.22 |
| 6 | – | – | – | 0.421 ± 0.04 |
| 7 | – | – | – | – |
| AUC0–6 (µg h/µl) | 0.339 | 6.243 | 6.666 | 8.844 |
Each value given in the table was calculated from n = 6 parallels and was given by the mean ± SD