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. 2010 Mar 17;132(14):5096–5104. doi: 10.1021/ja909180c

Figure 9.

Figure 9

(a) Model array showing cohybridization of fragmented CyDNA (E10) with Klenow labeled DNA (K): K Cy3/E10 Cy5 (left); K Cy3/K Cy5 (middle); E10 Cy3/K Cy5 (right). E10 yields 8- (Cy3) or 6-fold (Cy5) higher signals as evident by the red (E10 Cy5 (left)) and green (E10 Cy3 (right))-shifted fluorescence signal. (b) Comparative genome hybridization array (aCGH) of human genomic DNA (m (male) vs f (female)). Average fluorescence signal of aCGH probes for Cy3m vs Cy5f DNA as well as dye-swap control (Cy3f vs Cy5m) for Klenow labeling, (Klenow*, blue), Klenow or E10 labeling of adaptor linked DNA (white (K), orange (E10)). E10 labeling yields an up to 4-fold higher signal.