Table 2. MMP regulation in macrophages.
Effects of agonist and antagonists were measured on MMP mRNA and/or protein seretion form mature primary macrophages. For references consult the review (28). Abbreviations: CD40L, CD40 ligand; ConA, concanavalin A; IFN, interferon; IL, interleukin; IκB, inhibitor or nuclear factor κB; LDL, low-density lipoptein; LPS, lipopolysachharide; MMP, metalloproteinase; Ox, oxidised; PMA, phorbol myristate acetate; TNF, tumour necrosis factor.
| MMP | Agonist | Antagonist |
|---|---|---|
| MMP-1 | CD40L, cholesterol- feeding, LPS, S. aureus |
Cerivastatin, IFN-γ, IκBα, IL-4, IL-10, simvasatin |
| MMP-2 | LPS, T-cell medium or membranes |
Cerivastatin, simvasatin |
| MMP-3 | CD40L, cholesterol- feeding, LPS |
Cerivastatin, IFN-γ, IκBα, simvasatin |
| MMP-8 | CD40L, IL-1β, LPS, TNFα | |
| MMP-9 | IL-1β, LPS, ox-LDL, S. aureus, T-lymphocyte medium or membranes, TNFα |
Cerivastatin, fluvastatin, IFN-γ, IL-4, IL-10 |
| MMP-11 | CD40L | |
| MMP-12 | CD40L, cholesterol- feeding, IL-4, LPS |
IFN-γ |
| MMP-13 | LPS | IFN-γ |
| MMP-14 | LPS, TNFα | IFN-γ |
| MMP-16 | Ox-LDL, TNFα | |
| TIMP-1 | IL-6, IL-10, LPS, Ox-LDL, S. aureus |
IL-4, IL-8, IFNγ, Ox-LDL |
| TIMP-2 | None | |
| TIMP-3 | None | IFN-γ |