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. Author manuscript; available in PMC: 2010 Apr 7.
Published in final edited form as: Dev Cell. 2009 Jan;16(1):21–34. doi: 10.1016/j.devcel.2008.12.012

Figure 3. The role of caspase-8 in maintaining the survival of activated T cells.

Figure 3

Caspase-8 deficient T cells undergo necroptosis in response to antigen stimulation, which can be inhibited by necrostatin-1 (Nec-1). Autocrine secretion of TNFα is hypothesized to mediate necroptosis in activated caspase-8 deficient T cells.