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. Author manuscript; available in PMC: 2010 Apr 7.
Published in final edited form as: Dev Cell. 2009 Jan;16(1):21–34. doi: 10.1016/j.devcel.2008.12.012

Table 1.

The function of caspases in non-apoptotic processes.

Organism Caspase Non-Apoptotic Function
C. elegans CED-3 Immunity
Drosophila Dronc Compensatory proliferation, Dendritic pruning, Spermatogenesis, Neuronal differentiation, Border cell migration
Dredd Immunity
Drice Compensatory proliferation, Spermatogenesis, Neuronal differentiation
Dcp-1 Compensatory proliferation
Mammals Caspase-1 Innate immunity, Protein secretion
Caspase-2 Not determined
Caspase-3 Adaptive immunity, Lymphocyte proliferation, Erythroblast, Macrophage, Megakaryocyte, Lens epithelial cell, Skeletal muscle cell, Osteoblast, and Placental trophoblast differentiation, Stem cell maintenance
Caspase-4 Not determined
Caspase-5 Innate immunity
Caspase-6 Not determined
Caspase-7 Not determined
Caspase-8 Innate and adaptive immunity, Lymphocyte proliferation, Macrophage differentiation
Caspase-9 Not determined
Caspase-10 Not determined
Caspase-11 Innate immunity, Macrophage cell migration
Caspase-12 Not determined
Caspase-14 Keratinocyte differentiation