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. Author manuscript; available in PMC: 2010 Jun 28.
Published in final edited form as: Chem Commun (Camb). 2009 Mar 10;(24):3497–3510. doi: 10.1039/b821865j

Fig. 8.

Fig. 8

(a) Schematic of a liposome filled with a water shift reagent, [Tm(DOTMA)]. Water exchange rate across the liposomal membrane is the key determinant factor for LIPOCEST effect. (b) 1H NMR and Z-spectrum of [Tm(DOTMA)] LIPOCEST agent. (c) Lanthanide induced shift for water protons in 100 mM aqueous solution of [Ln-DTPA]2− complexes, and (d) influence of chelating ligands on lanthanide induced shift. Modified from Refs. 57, 67, and 78. (Permission Pending)