Table 2.
Demographic, clinical characteristics and anti-GAGA4 IgM levels of cohort-B
| FP (n = 167) | OND (n = 85) OIND, n = 33, ONIND, n = 52 | Ottawa (n = 177) | Brussels (n = 75) | |
| Mean age, years (SD) | 37(10)a | 44 (10) | 39(11) | 39(10) |
| Female, n (%) | 126 (75)a | 44 (52) | 128 (72)b | 42 (56) |
| Center Ottawa, n (%) | 121 (72) | 56(66) | NA | NA |
| Total IgM(mg/mL)0.5, corrected for gender, mean (SD) | 1.32 (0.27)c | 1.21 (0.28) | 1.29 (0.28) | 1.25 (0.26) |
| Anti-GAGA4 IgM, Units, mean (SD) | 47.7 (27.1)c | 36.7 (33.5) | 46.3 (32.3)b | 38.6 (22.2) |
| Anti-GAGA4 IgM, Units/Total IgM (mg/mL)0.5, corrected for gender, mean (SD) | 36.4 (23.1)c | 29.9 (23.2) | 35.5 (25.8) | 31.2 (15.4) |
Other inflammatory neurological disease (OIND) group included the following: 1 bacterial meningitis, 1 Aspergillus meningitis, 5 viral meningitis, 4 optic neuritis, 1 cerebral vasculitis, 1 vasculitic neuropathy, 1 cerebral malaria, 2 myelitis, 1 neurosarcoidosis, 1 chronic meningitis, 1 neurosyphilis, 3 HIV encephalopathy, 1 Sjögren encephalopathy, 1 Grave's disease, 4 Guilain-Barre syndrome, 1 chronic inflammatory demyelinating polyneuropathy, 1 acute disseminated encephalomyelitis, 1 Brachial plexopathy, 1 carcinomatous meningitis, 1 infectious meningitis of unknown origin; Other non-inflammatory neurological disease (ONIND) group included the following: 1 adrenomyelopathy, 1 amyotrophic lateral sclerosis, 2 anxiety, 3 idiopathic intracranial hypertension, 2 cerebrovascular disease, 1 cervical cancer, 2 neurodegenerative dementia, 2 degenerative disc disease, 2 diabetic retinopathy, 1 dizziness, 1 facial myokimia, 2 fibromyalgia, 1 glioblastoma multiforme, 8 idiopathic headache, 1 nerve palsy, 1 intermittent diplopia, 2 labyrinthitis, 1 left sixth nerve palsy, 1 lymphoma of cavum, 1 meningismus, 1 motor neuron disease, 1 motor neuropathy, 1 myelopathy, 1 neuralgia, 1 neurogenic bladder, 1 nystagmus, 1 optic neuropathy left eye, 2 papilledema, 1 pituitary tumor, 1 psychiatric disorder, 1 quadriplegia, 1 tingling NYD, 1 vertical diplopia/mild ptosis, 2 vertigo; NA, not applicable.
aP < 0.05 versus OND.
bP < 0.05 versus Brussels.
cMann–Whitney U-test Total IgM FP vs. OND P = 0.004; Anti-GAGA4 IgM FP vs. OND P < 0.0001; Anti-GAGA4 IgM corrected for gender FP vs.OND P = 0.0001.