Skip to main content
. 2008 Nov;14(9):1157–1174. doi: 10.1177/1352458508096878

Table 2.

Clinically isolated syndromes (CIS) in the differential diagnosis of MS

Type 1 CIS: clinically monofocal, at least one asymptomatic MRI lesion
Type 2 CIS: clinically multifocal, at least one asymptomatic MRI lesion
Type 3 CIS: clinically monofocal, MRI may appear normal; no asymptomatic MRI lesions
Type 4 CIS: clinically multifocal, MRI may appear normal; no asymptomatic MRI lesions
Type 5 CIS: no clinical presentation to suggest demyelinating disease, but MRI is suggestive

Note: symptomatic lesions should appear typical for demyelination; they may be located in the brain or cord, although more often occur in the brain; current evidence on the prognostic value of asymptomatic lesions comes mainly from brain imaging.