Table 1.

Characteristics of kidney disease cases and controls

Phenotype	Ancestry	Cases	Age at diagnosis	Controls	Age at enrollment
Idiopathic FSGS	AA	188a	38 ± 14	370b	44 ± 8
HIV-associated nephropathy	AA	53a	38 ± 8	241c	44 ± 6
Hypertensive ESKD	AA	696d	49 ± 16	948e	50 ± 12
Total		937		1559

All cases and control were of African ancestry.

^aIdiopathic focal segmental glomerulosclerosis (FSGS) cases and HIV-associated nephropathy (collapsing glomerulopathy) cases were diagnosed on kidney biopsy.

^bControls for idiopathic FSGS were normal blood donors from the NCI-Frederick Blood Donor Program and the NIH Clinical Center.

^cHIV-associated nephropathy controls were hypernormal controls, who had HIV infection for >8 years and had normal serum creatinine and normal urine protein excretion.

^dHypertensive ESKD cases were individuals in the southeastern USA who had a clinical diagnosis but generally did not undergo kidney biopsy; the age of hypertension diagnosis was 35 ± 13 years.

^eHypertensive ESKD controls were population (geographic) controls from the southeastern US, 192 of whom had hypertension diagnosed at 44 ± 13 years.