Table 3.

SNP association with H-ESKD for African American cases (n = 696) and controls (948), recessive model

SNP	Allele frequency		Unadjusteda		Adjusted for Chr 22 ancestryb	Adjusted for Chr 22 ancestry and rs2413396c
	H-ESKD	Controls	OR	P (FET)	Padj	Padj
rs5995283	0.99	0.98	1.83	0.07	0.049	0.24
rs6000240	0.96	0.94	1.69	0.003	0.004	0.013
rs16996677 (F-1)	0.37	0.27	2.33	6.3E−07	1.6E−06	0.013
rs16996674 (F-1)	0.35	0.23	2.77	2.4E−08	8.3E−09	0.0028
rs5756157	0.73	0.62	2.01	2.0E−11	8.1E−08	0.003
rs8136336	0.98	0.97	1.49	0.11	0.11	0.06
rs12159211	0.98	0.97	1.46	0.17	0.22	0.90
rs8138583	0.98	0.98	1.45	0.19	0.12	0.67
rs5995281	0.12	0.09	2.89	0.03	0.06	0.08
rs1005570	0.56	0.44	2.17	6.9E−11	2.2E−07	0.005
rs8141189	0.37	0.27	2.54	1.4E−07	5.6E−06	0.0011
rs2239784	0.69	0.55	2.19	1.4E−13	3.0E−09	0.012
rs1557539	0.98	0.98	1.04	1	0.78	0.88
rs9610489	0.19	0.20	0.77	0.37	0.89	0.32
rs1557538	0.70	0.64	1.40	0.001	0.007	0.64
rs1557536	0.73	0.68	1.40	0.001	0.031	0.80
rs5756152	0.39	0.25	3.11	1.7E−11	4.8E−13	1.53E−04
rs3752462 (E-1)	0.82	0.73	1.72	2.9E−07	4.1E−05	0.51
rs3830104	0.98	0.96	1.94	0.004	0.02	0.011
rs5750250 (S-1)	0.68	0.50	2.76	2.8E−21	4.0E−14	1.92E−05
rs7285745	0.98	0.97	1.48	0.10	0.08	0.64
rs2413396 (S-1)	0.68	0.53	2.41	9.6E−17	4.5E−11
rs1557529	0.49	0.34	2.54	2.1E−12	5.0E−11	0.0029
rs2239783	0.91	0.87	1.68	6.4E−05	0.0050	0.79
rs8137674	0.98	0.97	1.17	0.56	0.41	0.54
rs9619601	0.97	0.95	1.77	0.004	0.009	0.020
rs4821481 (E-1)	0.75	0.60	2.57	6.1E−20	5.6E−11	0.0003
rs2032487 (E-1)	0.76	0.61	2.54	3.9E−19	1.9E−10	0.0004
rs4821480 (E-1)	0.75	0.60	2.60	3.1E−20	3.2E−11	0.0001
rs2187776	0.32	0.29	1.11	0.52	0.91	0.021
rs5756133	0.91	0.85	1.93	1.8E−07	8.8E−04	0.31
rs9622373	0.96	0.95	1.32	0.14	0.09	0.92
rs16996648	0.40	0.26	3.79	5.2E−16	7.5E−13	7.59E−07
rs875725	0.94	0.93	1.24	0.19	0.26	0.07
rs6000233	0.36	0.34	1.10	0.55	0.62	0.013
rs1476009	0.98	0.97	1.81	0.01	0.01	0.027
rs11549907	0.95	0.94	1.36	0.09	0.13	0.018
rs11912763 (F-1)	0.34	0.19	5.65	5.1E−18	9.5E−16	2.62E−08
rs5756130	0.90	0.87	1.46	0.003	0.009	0.88
rs5756129g (L-1)	0.85	0.78	1.76	3.0E−07	5.7E−05	0.60
rs2071733	0.93	0.87	2.15	1.2E−08	3.3E−05	0.0018
rs2071732	0.98	0.96	2.17	0.001	0.004	0.005
rs735853g (L-1)	0.93	0.89	1.74	0.0001	0.0104	0.60
rs735854	0.87	0.79	1.85	6.3E−08	1.1E−04	0.050
rs12107g (L-1)	0.93	0.88	1.82	9.2E−06	1.2E−04	0.021
rs7078g (L-1)	0.90	0.84	1.59	9.8E−05	0.001	0.45

^aSignificant associations P≤ 0.001 are in bold; ^blogistic regression result adjusted for chr 22 ancestry; ^clogistic regression result adjusted for chr 22 ancestry and conditioned on rs2413396.