Table 5.

Haplotype associations with combined HIVAN and FSGS

	Haplotype associations				Strongest SNP in haplotype			Haplotype associations independent of E-1a				Haplotype associations independent of S-1a
	Dominant		Recessive					Dominant		Recessive		Dominant		Recessive
Haplotypeb	OR	P (FET)	OR	P (FET)		ORc	P (FET)	OR	P-value	OR	P-value	OR	P-value	OR	P-value
E-1	4.7	8.7E−06	5.0	4.9E−23	rs4821481	4.5 (rec)	1.3E−20	–	–	–	–	1.2	0.81	1.3	0.48
S-1	7.5	5.9E−10	6.0	9.7E−28	rs2413396	5.8 (rec)	4.4E−27	2.7	0.09	3.9	0.0001	–	–	–	–
F-1	3.8	3.1E−17	6.9	1.3E−10	rs11912763	3.8 (dom)	8.4E−17	2.2	2.4E−05	2.2	0.03	2.0	0.0005	2.2	0.04
L-1	8.2	3.2E−05	4.6	1.1E−18	rs735853	12.4 (rec)	1.1E−14	2.8	0.20	2.4	0.0001	1.6	0.59	1.9	0.01

^aHaplotypes considered as dominant and recessive variables together with dominant and recessive variables for E-1 or S-1, in logistic regression.

^bSNP alleles defining the haplotypes: E-1: rs4821480 G, rs2032487 C, rs4821481 C, rs3752462 T. S-1: rs5750248 T, rs2413396 C, rs5750250 G. F-1: rs11912763 A, rs16996674 T, rs16996677 A. L-1: rs7078 A, rs12107 G, rs735853 C, rs5756129 T.

^cOR and P-value for the model indicated for the OR.