Table 1.

GWAS results for sP-selectin

SNP	Chr	Position	Gene	Coded allele		Meta-analysis	ARIC (N = 673)	FHS (N = 3036)	RS (N = 406)
rs6136	1	167830575	SELP	T	P-value	4.05 × 10−61	2.7 × 10−3	2.33 × 10−59	0.002
					βa	0.226	0.358	0.242	0.117
					SE	0.014	0.119	0.015	0.037
					R2 b		0.8	7.9	2.2
rs760694	1	167835322	SELP	T	P-value	2.60 × 10−19	0.001	3.24 × 10−17	0.054
					βa	0.077	0.143	0.08	0.043
					SE	0.009	0.044	0.01	0.022
					R2 b		1.2	2.2	0.9
rs2235302	1	rs2235302	SELP	T	P-value	3.95 × 10−16	0.020	8.01 × 10−14	0.01
					βa	−0.073	−0.109	−0.074	−0.058
					SE	0.009	0.047	0.01	0.024
					R2 b		0.9	1.8	1.3
rs579459	9	135143989	ABO	T	P-value	1.86 × 10−41	0.00001	3.29 × 10−33	3.61 × 10−6
					βa	0.140	0.223	0.139	0.125
					SE	0.010	0.051	0.012	0.027
					R2 b		2.7	4.6	4.7

^aβ calculated using log-transformed sP-selectin values.

^bPercentage of sP-selectin variance explained by the SNP reported.