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. Author manuscript; available in PMC: 2010 Apr 7.
Published in final edited form as: J Thorac Cardiovasc Surg. 2009 Oct 23;139(2):489–493. doi: 10.1016/j.jtcvs.2009.05.049

Figure 1.

Figure 1

Figure 1

Figure 1

Figure 1

(A): Sham wash (Mixed cortical cultures), (B) : Ibuprofen (100 μg/ml) alone, (C) : Mixed cortical cultures were exposed to 12.5 μM NMDA for 24 hours and demonstrated an acute swelling of neuronal cell bodies followed by a widespread necrotic neuronal degeneration resulting in disrupted neurons and segmentalized neuritis, (D) : Ibuprofen at a concentration of 100 μg/ml was co-applied in the medium with excitotoxin (NMDA). Ibuprofen preserved neuronal cells and protected neurites. Original magnification is X200. Scale bars indicated 100 μm.

NMDA : N-methyl-D-aspartate, Ib : Ibuprofen.