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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2009 Aug 25;81(4):385–390. doi: 10.1136/jnnp.2009.183525

Table 1.

Methodological details of the six ALS Registers used to estimate epidemiology of ALS in Europe.

Sources of case information Population size Year case ascertainment commenced Area (km2)
Ireland4,8 ALS specialist clinics, neurologists, neurophysiologists, neuropathologists, neurosurgeons, primary care physicians, and local charitable organizations 3,917,203 (2002 census) 1993 70,273
Lancashire, UK3 ALS specialist clinics, neurologists, neurophysiologists, hospital discharge databases 1,623,667 (2001 census) 1986 5,706
Lombardy, Italy7 ALS specialist clinics, neurologists, neurophysiologists, hospital discharge databases, and local charitable organizations 4,947,554 (2001 census) 1998 23,851
Piemonte, Italy5 ALS specialist clinics, neurologists, and hospital discharge databases 4,341,733 (2006 est.) 1995 28,662
Puglia, Italy6 ALS specialist clinics, neurologists, hospital discharge database, and local charitable organizations 4,086,613 (2001 census) 1998 19,357
Scotland1,2 ALS specialist clinics, neurologists, neurophysiologists, hospital discharge databases, mortality databases, and local charitable organizations 5,062,011 (2001 census) 1989 78,772