Table 2.

Age and gender-specific incidence of ALS per 100,000 person-years among those 18 years and over based on combined data from the six European ALS Registers for the two year period, 1998 - 1999

	Males				Females				Total
Agea	Casesb	Person-yearc	Incidenced	95% CI	Cases	Person-year	Incidence	95% CI	Cases	Person-year	Incidence	95% CI
18-19	2	596,328	0.3	0.0-0.8	0	571,361	-	-	2	1,167,688	0.2	0.0-0.4
20-24	1	1,563,778	0.1	0.0-0.2	1	1,525,677	0.1	0.0-0.2	2	3,089,455	0.1	0.0-0.2
25-29	6	1,720,225	0.3	0.1-0.6	6	1,706,432	0.4	0.1-0.6	12	3,426,657	0.4	0.2-0.5
30-34	5	1,856,398	0.3	0.0-0.5	2	1,859,155	0.1	0.0-0.3	7	3,715,553	0.2	0.0-0.3
35-39	11	1,869,135	0.6	0.2-0.9	3	1,885,445	0.2	0.0-0.3	14	3,754,580	0.4	0.2-0.6
40-44	24	1,693,896	1.4	0.8-2.0	14	1,710,534	0.8	0.4-1.2	38	3,404,430	1.1	0.8-1.5
45-49	35	1,565,127	2.2	1.5-3.0	23	1,582,262	1.5	0.9-2.0	58	3,147,389	1.8	1.4-2.3
50-54	38	1,606,043	2.4	1.6-3.1	37	1,615,772	2.3	1.6-3.0	75	3,221,815	2.3	1.8-2.9
55-59	77	1,348,148	5.7	4.4-7.0	39	1,385,152	2.8	1.9-3.7	116	2,733,300	4.2	3.5-5.0
60-64	72	1,280,496	5.6	4.3-6.9	79	1,367,302	5.8	4.5-7.1	151	2,647,798	5.7	4.8-6.6
65-69	95	1,098,073	8.7	6.9-10.4	84	1,261,865	6.7	5.2-8.1	179	2,359,938	7.6	6.5-8.7
70-74	96	900,352	10.7	8.5-12.8	76	1,170,278	6.5	5.0-8.0	172	2,070,630	8.3	7.1-9.5
75-79	63	649,547	9.7	7.3-12.1	69	990,265	7.0	5.3-8.6	132	1,639,811	8.0	6.7-9.4
80-84	24	324,676	7.4	4.4-10.3	24	602,654	4.0	2.4-5.6	48	927,330	5.2	3.7-6.6
>85	5	245,499	2.0	0.3-3.8	17	643,615	2.6	1.4-3.9	22	889,113	2.5	1.4-3.5
Total	554	18,317,722	3.0	2.8-3.3	474	19,877,768	2.4	2.2-2.6	1028	38,195,487	2.7	2.5-2.9

^aAge at diagnosis

^bNumber of cases of ALS diagnosed in the six European ALS registers for the two year period, 1998-1999

^ccombined person-years for the six European for the two year period, 1998-1999

^dper 100,000 person-years