Table 4.

Crude and adjusted incidence per 100,000 person-years of ALS by catchment area and site of onset

Registry	Cases	Denominator (person years)	Incidence	95% CI	Adjusted Incidence	95% CI
Lancashire
Spinal	32	3,246,334	0.9	0.6-1.2	0.9	0.6-1.2
Generalized + Bulbar	22	3,246,344	0.6	0.4-0.9	0.6	0.3-0.9
Ireland
Spinal	76	7,455,000	1.0	0.8-1.3	1.3	1.0-1.6
Generalized + Bulbar	72	7,455,000	1.0	0.7-1.2	1.3	1.0-1.6
Lombardy
Spinal	132	9,895,108	1.3	1.1-1.6	1.2	1.0-1.4
Generalized + Bulbar	58	9,895,108	0.6	0.4-0.7	0.5	0.4-0.7
Piemonte
Spinal	182	8,815,564	2.1	1.8-2.4	1.7	1.5-2.0
Generalized + Bulbar	83	8,815,564	0.9	0.7-1.1	0.8	0.6-0.9
Puglia
Spinal	96	7,959,576	1.2	1.0-1.4	1.2	1.0-1.4
Generalized + Bulbar	34	7,959,576	0.4	0.3-0.6	0.4	0.3-0.6
Scotland
Spinal	153	10,124,022	1.5	1.3-1.8	1.5	1.3-1.7
Generalized + Bulbar	41	10,124,022	0.4	0.3-0.5	0.4	0.3-0.5