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. Author manuscript; available in PMC: 2010 Apr 7.
Published in final edited form as: Methods Mol Biol. 2009;500:335–359. doi: 10.1007/978-1-59745-525-1_12

Fig. 6.

Fig. 6

Binding of proteins to lattices depends on their geometry. (A) Protein geometry parameters are minimal binding site, M, and occlusion site, S. (B) If lattice length, N < M, binding free energy is approximately proportional to N. (C) If N > M, the observed KD is inversely proportional to the number of alternative binding configurations, N − M + 1. (D) If more than one protein can bind to a lattice molecule, N ≥S + M, binding configurations for all possible numbers of bound proteins have to be considered.