Table 2.

Biochemical Kinetic Model Parameters

Name	Description	Value	Units	Reference
KD, ATP	ATP-p38 affinity	67	uM	In-house measurement
KD, ATF2	ATF2-p38 affinity	38	uM	[30]
KD, MK2	MK2-p38 affinity	20	nM	[31]
kcat, ATF2	p38-ATF2 catalytic rate	1.2	s-1	[30]
kcat, MK2	p38-MK2 catalytic rate	0.17 2.4	s-1 s-1	[31] In-house measurement
[p38]	p38 (active) initial condition	0.5	nM
[ATP]	ATP initial condition	50	uM
[ATF2]	ATF2 initial condition	100	nM
[MK2]	MK2 initial condition	10	nM