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. 2010 Apr 7;5(4):e10058. doi: 10.1371/journal.pone.0010058

Figure 1. Pregnant SD and BN dams exhibit different susceptibility to alcohol in their thyroid function.

Figure 1

(A) Plasma TSH, (B) total T3, (C) free T3 and (D) free T4 levels in control (C), pair-fed (PF), and ethanol-consuming (E) mothers on gestational day 21 (G21). SD mothers include those mated to SD or BN males; BN mothers include those mated to SD or BN males. Alcohol-containing and calorie-restricted diets suppressed plasma TSH levels (F [2, 57] = 9.3, P<0.01) and increased T3 (F [2, 58] = 4.0, P = 0.02) and fT3 (F [2, 49] = 5.6, P<0.01) levels. Plasma fT4 was decreased by alcohol consumption in SD but not BN mothers (F [2, 56] = 5.5, P<0.01). Plasma T3 levels (F [1, 58] = 28.0, P<0.001) and fT4 (F [1, 56] = 11.1, P<0.01) were higher in BN mothers than SD mothers while fT3 levels were lower in BN (F [1, 49] = 4.1, P<0.05). All data (means {plus minus} SEM) were analyzed by two-way ANOVAs and Bonferroni post-hoc results are shown (**P<0.01).