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. 2010 Apr 7;5(4):e10058. doi: 10.1371/journal.pone.0010058

Figure 2. Diet effects on fetal bodyweight are modulated by maternal and paternal genetic backgrounds.

Figure 2

Fetal bodyweight of C, PF, and E male and female fetuses (SD/SD, SD/BN, BN/SD, and BN/BN where maternal strain is first) on G21. Means from individual litters were used to calculate group final means ± SEM as shown. Males (A) and females (B) were separated due to the effect of fetal sex on bodyweight (F [1, 71] = 4.5, P = 0.04). Fetuses obtained from hybrid crosses weighed more than pure-strain fetuses on G21 (F [1, 71] = 53.0, P<0.001). Alcohol exposure decreased fetal weight (F [2, 71] = 15.7, P<0.001), but BN/BN fetuses were not as vulnerable as BN/SD fetuses (maternal strain x paternal strain x diet: F [2, 71] = 5.6, P<0.01). Data were analyzed by four-way ANOVA with sex as a factor. Planned comparisons were made with Bonferroni adjustment (+P<0.0001). Comparisons are relative to the control group of the same fetal strain unless otherwise indicated.