Figure 3. Unique bodyweight deficit of alcohol-exposed BN/SD illustrates the interaction of both parental genetic backgrounds in fetal vulnerability to alcohol.

The difference in mean bodyweight between control and alcohol-exposed male and female fetuses is shown for the pure and hybrid fetal strains. There was no significant effect of fetal sex on bodyweight deficits; therefore, data were analyzed by one-way ANOVA with fetal strain as the factor. Bodyweight deficits exhibited by BN/SD fetuses were significantly greater than all other strains (fetal strain: F [3], [30] = 25.8, P<0.0001) including the BN/BN fetuses of the same mother, illustrating a maternal-paternal interaction of genetic background. *** P<0.001 by Bonferroni post-hoc test.