Table 5.
Multivariate Analysis of Risk Factors for Cognitive Symptoms
| Variable | No. of Pts | MMQ* | SEE | p-value | NBRS* | SEE | p-value |
|---|---|---|---|---|---|---|---|
| Diagnosis | |||||||
| Myeloid | 68 | 0.12 | (0.14) | NS | 0.31 | (0.44) | NS |
| Lymphoid | 69 | −0.08 | (0.18) | −0.38 | (0.54) | ||
| CML | 24 | −0.04 | (0.17) | −0.39 | (0.53) | ||
| NM | 53 | --- | --- | ||||
| Prior Therapy | |||||||
| Less | 143 | --- | --- | ||||
| More | 71 | 0.43 | (0.12) | 0.001 | 0.74 | (0.37) | 0.05 |
| Cranial Rads | |||||||
| No | 170 | -- | --- | ||||
| Yes | 44 | −0.40 | (0.13) | 0.002 | −0.50 | (0.38) | NS |
| Gender | |||||||
| Female | 96 | --- | --- | ||||
| Male | 118 | −0.11 | (0.07) | NS | −0.53 | (0.21) | 0.01 |
| Age at BMT | |||||||
| <13 years | 110 | --- | --- | ||||
| >13 years | 104 | −0.14 | (0.07) | 0.04 | −0.32 | (0.21) | NS |
Abbreviations: MMQ = Modified Memory Questionnaire where higher values worse, NBRS = Neurobehavioral Rating Scale where higher values worse, Lymphoid = Acute lymphoblastic leukemia, Hodgkin Disease, Non-Hodgkin lymphoma, Myeloid = Acute Myelogenous Leukemia myelodysplastic syndrome, juvenile myelomonocytic leukemia, CML = Chronic Myelogenous Leukemia, NM= non-malignant includes Aplastic Anemia, immune deficiency, red cell aplasia, Less Therapy = first remission therapy only or no therapy, more therapy = second or subsequent remission therapy or relapse or cranial irradiation, Cranial rads = cranial irradiation. SEE = Standard Error of the Estimate
Numbers reflect mean differences relative to reference group
--- = reference group.