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. 2010 Apr 7;10:e24.

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Copyright © 2010 The Author(s)

This is an open-access article whereby the authors retain copyright of the work. The article is distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functional clustering of the genes present within the keloid susceptibility loci. Selected genes present within keloid susceptibility loci, 7p11 and 2q23, have been functionally clustered using DAVID Bioinformatics Resources 2008 Functional Annotation Tool. The genes are separated into 9 separated category, and at least 1 gene from each categories has been selected for downstream quantitative polymerase chain reaction analysis. The selected genes are marked with a box around them. EGFR indicates epidermal growth factor receptor; BIN1, bridging integrator 1; LIMS2, LIM and senescent cell antigen-like domains 2; MAP3K2, mitogen-activated protein kinase kinase kinase 2; TNFAIP6, tumor necrosis factor-α inducible protein 6; ACVR2A, activin receptor IIA; DPP10, inactive dipeptidyl peptidase 10; and MYO7B, myosin VIIB.