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. Author manuscript; available in PMC: 2010 Apr 8.
Published in final edited form as: Circ Cardiovasc Genet. 2009 Dec 3;3(1):22–30. doi: 10.1161/CIRCGENETICS.109.862748

Table 7.

Epidemiological Summaries of the Clinical Predictive Value of the PRIM-Defined Subsamples

Subsample
High Risk Low Risk Sensitivity Specificity +PV*
FS 2 and FS 1 FS 3 0.735 0.588 0.118
FS 1 FS 3 and FS 2 0.412 0.808 0.139
FS 1-1 FS 3 and FS 2 and FS 1-2 0.206 0.926 0.172
Marginal Estimates
High Risk Low Risk Sensitivity Specificity +PV*
ATTT/ATAG ATAT/others 0.451 0.596 0.077
Smoke† No smoke 0.642 0.435 0.079
Hypertension‡ No hypertension 0.763 0.386 0.085
TG ≥ 150 mg/dL TG <150 mg/dL 0.529 0.600 0.090
>65 y 45 to 65 y 0.770 0.503 0.104
*

+PV reflects an expected proportion of IHD cases assigned to the related high-risk group. The estimate of +PV is related to sensitivity and specificity of a risk stratification algorithm that uses subsamples as a tool to identify individuals who are at increased risk and the prevalence of the proposed high-risk subsample in the population of interest through a mathematical formula that is derived from the application of the Bayes’ theorem of conditional probabilities (Fletcher and Fletcher49).

†

History of smoking.

‡

History of hypertension.