Data from a subset of compounds identified in the high throughput screens. The structures of two known PDE inhibitors (rolipram and zardaverine), along with members of the coumarin, furanocoumarin, and furanochromone compound classes are presented, along with the Composite Z scores obtained from duplicate plates for each of the four target PDEs are presented. Composite Z scores that exceed the 8.53 cut-off, considered a hit in the screen, are in bold and underlined. Trioxsalen and khellin were identified from both the Microsource Spectrum and Prestwick Bioactive libraries.