TABLE I. Characteristics of Patients with Fore-/Midgut Net According to Functional Activity, Site and KI-67 Proliferation Index.
Tumor no. | Diagnosis | Origin | Behavior | Ki-67 (%) | CIMP | MSI (marker) | LOH (marker) | Follow-up time (weeks) | Survival | Gender | Age at diagnosis |
---|---|---|---|---|---|---|---|---|---|---|---|
8 | Insulinoma | Pancreas | Malignant | <2 | − | MSS | − | 12 | tu | m | 79 |
14 | Insulinoma | Pancreas | Benign | <2 | − | MSS | − | 192 | Survived | f | 52 |
16 | Insulinoma | Pancreas | Benign | <2 | + | MSS | − | 60 | Survived | f | 77 |
19 | Insulinoma | Pancreas | Malignant | 2–20 | − | MSS | + (D5S346) | 12 | tu | f | 79 |
12 | Gastrinoma | Pancreas | Benign | 2–20 | − | MSS | na | 36 | tu | m | 81 |
2 | Vipoma | Pancreas | Malignant | 2–20 | − | MSS | − | 60 | Survived | m | 56 |
17 | Vipoma | Pancreas | Benign | 2–20 | + | MSS | − | 76 | Survived | m | 56 |
1 | Glucagonoma | Pancreas | Malignant | 2–20 | − | MSS | − | 8 | tu | f | 50 |
5 | Nonfunctional | Pancreas | Malignant | <2 | + | MSS | na | 84 | Survived | m | 61 |
4 | Nonfunctional | Pancreas | Malignant | 2–20 | − | MSS | na | 72 | Survived | f | 36 |
28 | Nonfunctional | Duodenum | Malignant | <2 | + | MSS | − | 96 | Survived | m | 71 |
34 | Nonfunctional | Duodenum | Malignant | <2 | − | MSI-L | na | 98 | Survived | f | 81 |
37 | Nonfunctional | Duodenum | Malignant | <2 | + | MSS | − | 96 | Survived | m | 70 |
9 | Nonfunctional | Duodenum | Malignant | 2–20 | − | MSS | na | 12 | tu | m | 78 |
30 | Nonfunctional | Duodenum | Malignant | 2–20 | − | MSS | na | 35 | tu | m | 70 |
6 | Gastrinoma | Duodenum | Malignant | <2 | − | MSI-L | na | 10 | tu | f | 49 |
15 | Gastrinoma | Duodenum | Benign | <2 | − | MSS | − | 192 | Survived | m | 48 |
18 | Gastrinoma | Duodenum | Benign | <2 | − | MSS | − | 50 | Survived | f | 49 |
3 | Gastrinoma | Duodenum | Benign | 2–20 | − | MSS | + (D2S123) | 48 | Survived | m | 66 |
23 | Carcinoid syndrome | Ileum | Malignant | <2 | − | MSS | − | 84 | Survived | m | 62 |
24 | Carcinoid syndrome | Ileum | Malignant | <2 | + | MSS | − | 72 | Survived | m | 66 |
25 | Carcinoid syndrome | Ileum | Malignant | <2 | − | MSS | − | 72 | Survived | m | 70 |
32 | Carcinoid syndrome | Ileum | Malignant | <2 | + | MSS | − | 120 | Survived | m | 63 |
35 | Carcinoid syndrome | Ileum | Malignant | <2 | + | MSS | − | 36 | tu | f | 56 |
38 | Carcinoid syndrome | Ileum | Malignant | <2 | − | MSS | na | 144 | Survived | f | 60 |
33 | Carcinoid syndrome | Jejunum | Malignant | <2 | − | MSS | − | 120 | Survived | m | 75 |
36 | Carcinoid syndrome | Jejunum | Malignant | <2 | − | MSS | na | 60 | Survived | m | 69 |
13 | Nonfunctional | Ileum | Malignant | <2 | + | MSS | − | 36 | tu | f | 81 |
21 | Nonfunctional | Ileum | Malignant | <2 | − | MSS | na | 84 | Survived | f | 61 |
22 | Nonfunctional | Ileum | Malignant | <2 | + | MSS | na | 84 | Survived | f | 61 |
20 | Nonfunctional | Ileum | Malignant | 2–20 | + | MSS | + (D17S250) | 36 | tu | m | 66 |
29 | Nonfunctional | Ileum | Malignant | 2–20 | − | MSI-L | na | 35 | tu | f | 38 |
31 | Nonfunctional | Ileum | Malignant | 2–20 | − | MSS | + (D17S250) | 24 | tu | m | 70 |
10 | Nonfunctional | Jejunum | Malignant | <2 | − | MSS | na | 12 | tu | m | 71 |
26 | Nonfunctional | Jejunum | Malignant | <2 | − | MSS | − | 84 | Survived | f | 49 |
27 | Nonfunctional | Jejunum | Malignant | <2 | + | MSS | − | 120 | Survived | m | 51 |
7 | Nonfunctional | Jejunum | Malignant | 2–20 | − | MSS | − | 10 | tu | m | 65 |
11 | Nonfunctional | Jejunum | Malignant | 2–20 | − | MSI-L | na | 12 | tu | f | 38 |
na, not available; tu, died from the tumor; f, female; m, male.