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. Author manuscript; available in PMC: 2010 Apr 8.
Published in final edited form as: N Engl J Med. 1997 Oct 2;337(14):986–994. doi: 10.1056/NEJM199710023371407

Figure 1. Effect of Caloric Restriction, Initiated at 1 Month or 12 Months of Age, on Body Weight and Life Span in Mice.

Figure 1

Panels A and B show data from female C3B10F1 mice subjected to restricted caloric intake (40, 50, or 85 kcal per week) starting at one month of age.9 The maximal life span (inset, Panel B) is the mean survival for the longest-lived decile of each group. Panels C and D show data from male B10C3F1 mice subjected to restricted caloric intake (90 kcal per week) as compared with control mice (160 kcal per week), starting at 12 months of age.10 Caloric restriction at both ages extended both average and maximal life span. Each symbol in the survival curves (Panels B and D) represents one mouse. The bars in Panels A and C represent standard deviations. (Data in panels A and B are from Weindruch et al.10; data in panels C and D are from Weindruch and Walford.11)