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. Author manuscript; available in PMC: 2010 Apr 8.
Published in final edited form as: J Eval Clin Pract. 2009 Dec;15(6):1142–1151. doi: 10.1111/j.1365-2753.2009.01315.x

Table 2.

The Contingent Variables

Variable Match level Mismatch level Remarks
Global improvement CGI progress = 6, much worse over the past 6 months CGI progress = 3, minimally improved over the past 6 months 3 is at the YPSA threshold for an insufficient response; 6 is below the threshold
Patient’s condition CGI severity = 6, severe illness at present CGI severity = 4, moderate illness at present 4 is at the YPSA threshold for an insufficient response; 6 is below the threshold
Guideline step Step 2, failed one course of antipsychotic treatment Step 4, failed three courses of antipsychotic treatment: 3 medications in 2 different classes Step 4 indicates poor long-term response and treatment resistance; clinical studies recommend clozapine (a jump to step 5, outside the guideline)
Patient adherence High: Almost always takes medications as prescribed (more than 75% of the time) Low: Almost never takes medications as prescribed (less than 25% of the time) Low adherence discourages switches, owing to increased risks and greater likelihood of non-response