Table 2.
Mean (SD) baseline values for different variables defined by quarters of distribution of cholestanol at baseline (<107, 107-126, 127-148, >148)
| Variables | First quarter
|
Second quarter
|
Third quarter
|
Fourth quarter
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Simvastatin (n=106) | Placebo (n=111) | Simvastatin (n=106) | Placebo (n=111) | Simvastatin (n=113) | Placebo (n=104) | Simvastatin (n=110) | Placebo (n=107) | ||||
| Age (years) | 58.2 (6.9) | 58.0 (5.8) | 57.3 (6.9) | 57.0 (7.4) | 58.5 (6.3) | 58.0 (6.4) | 58.5 (6.4) | 58.1 (6.2) | |||
| Body mass index (kg/m2) | 28.6 (3.7) | 28.0 (3.9) | 27.0 (3.5) | 26.9 (3.6) | 26.1 (2.6) | 26.4 (3.1) | 25.3 (3.1)* | 25.0 (2.8)* | |||
| Cholesterol (mmol/l) | 6.45 (0.75) | 6.67 (0.72) | 6.64 (0.71) | 6.62 (0.85) | 6.60 (0.75) | 6.51 (0.75) | 6.60 (0.85) | 6.65 (0.73) | |||
| LDL cholesterol (mmol/l)† | 4.50 (0.70) | 4.71 (0.66) | 4.70 (0.70) | 4.70 (0.80) | 4.68 (0.73) | 4.58 (0.70) | 4.68 (0.83) | 4.71 (0.74) | |||
| HDL cholesterol (mmol/l) | 1.18 (0.289 | 1.15 (0.25) | 1.19 (0.31) | 1.19 (0.34) | 1.25 (0.34) | 1.21 (0.32) | 1.32 (0.33)* | 1.33 (0.33)* | |||
| Triglycerides (mmol/l) | 1.74 (0.69) | 1.81 (0.66) | 1.66 (0.63) | 1.67 (0.66) | 1.48 (0.59) | 1.57 (0.64) | 1.30 (0.52)* | 1.31 (0.60)* | |||
| Cholestanol (102 mmol/mol cholesterol)‡ | 91 (13) | 92 (12) | 117 (6) | 116 (6) | 136 (6) | 135 (6) | 171 (19) | 172 (26) | |||
LDL=low density lipoprotein; HDL=high density lipoprotein.
*
P<0.0001 by analysis of variance.
†
Total and LDL cholesterol values differed in first quarter by pairwise comparison but by analysis of variance the two quartile lines were similar.
‡
Lowest cholestanol values in fourth quarters were 148 for both groups.