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. Author manuscript; available in PMC: 2010 Apr 8.
Published in final edited form as: Ophthalmology. 2009 Jan 22;116(3):504–512. doi: 10.1016/j.ophtha.2008.10.017

Table 3.

Univariate and Multivariate Regression Analyses of Baseline Visual Acuity on Baseline Demographic and Clinical Characteristics

Central Retinal Vein Occlusion
 Branch Retinal Vein Occlusion
Univariate
 Multivariate
(N =232)
 Univariate
 Multivariate
(N = 374)
N Beta* Punadj Phoch Beta* Punadj Phoch N Beta* Punadj Phoch Beta* Punadi Phoch
Baseline Demographic and Clinical Center Characteristics
    Age (per 10-y
  interval)		 262 −2.41 0.0006 0.04 −2.96 0.0004 0.03 403 −1.39 0.02 0.94 −1.58 0.0077 0.47
    Female gender 262 −1.81 0.30 0.98 −0.18 0.92 0.98 403 −2.60 0.04 0.98 −2.75 0.03 0.98
    White 262 0.90 0.77 0.98 2.28 0.46 0.98 403 1.74 0.39 0.98 1.06 0.57 0.98
    Duration of macular
  edema (per month)		 262 −0.49 0.05 0.98 −0.83 0.0006 0.04 403 0.27 0.11 0.98 0.05 0.78 0.98
    With prior grid laser 403 −0.85 0.73 0.98 −3.21 0.19 0.98
    With dense macular
  hemorrhage		 403 −3.58 0.01 0.60 −1.09 0.45 0.98
    With prior lens
  extraction		 262 −1.17 0.60 0.98 1.16 0.63 0.98 403 −0.44 0.79 0.98 1.52 0.36 0.98
    Prior diabetes mellitus 262 −1.15 0.58 0.98 −0.76 0.72 0.98 403 −0.99 0.59 0.98 −2.26 0.19 0.98
    Prior hypertension 262 −3.52 0.06 0.98 −0.78 0.68 0.98 403 0.35 0.80 0.98 0.45 0.73 0.98
    With coronary heart
  disease		 262 −2.88 0.19 0.98 −0.07 0.98 0.98 403 −3.60 0.03 0.98 −3.01 0.07 0.98
Optical Coherence Tomography Characteristics
    Center point
  thickness (per 100
  µm)		 262 −1.67 <0.0001 0.0007 −1.40 0.0033 0.22 403 −1.93 <<0.0001 <0.0001 −2.14 <0.0001 <0.0001
    With subretinal fluid 257 6.24 0.0003 0.02 5.05 0.0036 0.24 394 1.33 0.34 0.98 3.70 0.0061 0.38
    With any cystoid
  spaces		 262 −0.43 0.87 0.98 3.80 0.22 0.98 399 3.07 0.07 0.98 6.46 0.0001 0.01
    Size of cystoid spaces 262 399
    Absent (reference) 30 – 72 –
    Small (≤200 µm) 33 −1.02 0.77 0.98 89 1.76 0.38 0.98
    Medium (201–400
  µm)		 108 0.89 0.76 0.98 171 4.81 0.0072 0.45
    Large (≥401 µm) 91 −1.79 0.54 0.98 67 0.37 0.86 0.98
    Total macular volume
  (mm3)		 171 −2.45 <0.0001 <0.0001 250 −0.84 0.05 0.98
Color Fundus Photograph Characteristics
    Retinal thickening
  within the grid (per
  DA)		 252 −0.53 0.0037 0.24 0.10 0.69 0.98 388 −1.34 <0.0001 <0.0001 −0.65 0.03 0.98
    Retinal hemorrhage
  within the grid (per
  DA)		 257 −1.23 <0.0001 0.0003 −0.44 0.18 0.98 390 −1.14 <0.0001 0.0011 0.12 0.73 0.98
Fluorescein Angiogram Characteristics
    Leakage within the
  grid (per DA)† 		248 −0.77 <0.0001 0.0012 −0.66 0.0052 0.33 393 −1.34 <0.0001 <0.0001 −0.48 0.15 0.98
    Capillary loss within
   the eye (per DA)† 		190 −0.72 0.31 0.98 287 −0.08 0.49 0.98
    >5 DA of capillary
  loss within the eye† 		190 1.68 0.84 0.98 287 −0.50 0.81 0.98

DA = disc area; Punadj = unadjusted P value. Phoch= adjusted Hochberg P value.

*

Estimate of change in the baseline visual acuity letter score associated with a unit increase of a continuous independent variable (e.g., 10-y increase for age) or an increase in level of a categoric or binary independent variable (e.g., prior grid laser compared to without prior grid laser) (5 letters is 1 line on the electronic Early Treatment Diabetic Retinopathy Study [E-ETDRS] chart).

†

Total macular volume and capillary loss within the eye were excluded from the multiple regression analyses because of the large number of missing data points.

Bolding within the cells of tables identifies factors significant at Phoch<0.05.