Table 1.
—Baseline Characteristics and Outcome of Transfusion-Associated Circulatory Overload, Transfusion-Related Acute Lung Injury, and Matched Controls
| Medical Variables | TRALI/Possible TRALI(n = 74) | TRALI Controls(n = 74) | TACO(n = 51) | TACO Controls(n = 51) |
| Age (SD), y | 61.2 (17.8) | 62.5 (17.6) | 69.8 (14.9) | 71.5 (14.2) |
| Female gender, No. (%) | 37 (50) | 37 (50) | 24 (47.1) | 24 (47.1) |
| APACHE III scores | 61 (44-75) | 57 (45-81) | 24 (17-41) | 24 (16-42) |
| Chronic liver disease, No. (%) | 20 (27.4)a | 11 (15.1) | 10 (19.6) | 6 (11.8) |
| Sepsis, No. (%) | 27 (36.5)a | 16 (21.6) | 10 (19.6) | 9 (17.7) |
| Number of associated transfusions, median (IQR) | 3 (1-5) | 2 (1-3) | 3 (2-6)a | 2 (2-3) |
| ICU LOS, days | 4.7 (2.4-7.8)a | 2.1 (1.1-5.3) | 3.0 (1.9-4.2)a | 1.7 (1.0-3.1) |
| Hospital LOS, days | 11.5 (7.0-19.3)a | 7.8 (3.6-14.0) | 9.4 (5.7-13.8)a | 6.1 (3.9-10.0) |
| Hospital mortality, No. (%) | 32 (43.2)a | 18 (24.3) | 4 (7.8) | 6 (11.8) |
| 1-y mortality, No. (%)b | 46 (63.8)a | 33 (46.4)a | 19 (38.0) | 14 (28.0) |
| 2-y mortality, No. (%)c | 52 (74.3)a | 38 (54.3)a | 22 (44.9) | 19 (38.8) |
APACHE = Acute Physiology and Chronic Health Evaluation; IQR = interquartile range; LOS = length of stay; TACO = transfusion-associated circulatory overload; TRALI = transfusion-associated acute lung injury.
a
Significant difference between cases and controls (P < .05).
b
71 pairs of TRALI and controls, 50 pairs of TACO and controls.
c
70 pairs of TACO and controls; 49 pairs of TACO and controls.