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. 2010 Apr 8;6(4):e1000901. doi: 10.1371/journal.pgen.1000901

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Hindlimb buds skeletons at E14.5, stained with alcian blue (cartilage) and alizarin red (bone). Prx1-Cre mediated inactivation of Hand2 (H2 ^Δ/Δc) in hindlimb buds results in all cases in fusion of the tarsals (arrowheads) and formation of 5 (n = 11/24) or 4 (n = 13/24) digits. Please note that in latter case the formation of digit 2 and/or 3 (not shown), which depend mostly on long-range SHH signaling [7] is always affected. (B) Shh expression in wild-type and Hand2 deficient hindlimb buds at E10.75 (37 somites). Note that the expression domain is correctly positioned in H2 ^Δ/Δc hindlimb buds, but expression levels are reduced.