Table 2.
Genotype frequency distribution and association with stroke outcome at three months for MMP-2 SNPs.
| Whole sample* | Ischemic subset† | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype frequency | Genotype frequency | ||||||||
| SNP | Genotype | Good recovery, n (%) | Poor recovery, n (%) | OR [95%CI] | P | Good recovery, n (%) | Poor recovery, n (%) | OR [95%CI] | P |
| rs243866 | |||||||||
| G/G | 142 (67.6) | 117 (57.9) | 1.67 [1.10-2.52] | 0.0143 | 125 (67.6) | 83 (56.8) | 1.78 [1.13-2.80] | 0.0128 | |
| A/G | 66 (31.4) | 76 (37.6) | 59 (31.9) | 55 (37.7) | |||||
| A/A | 2 (1.0) | 9 (4.5) | 1 (0.5) | 8 (5.5) | |||||
| rs243865 | |||||||||
| C/C | 141 (67.8) | 117 (57.9) | 1.65 [1.09-2.50] | 0.0162 | 124 (67.8) | 83 (56.8) | 1.76 [1.12-2.78] | 0.0143 | |
| C/T | 65 (31.2) | 76 (37.6) | 58 (31.7) | 55 (37.7) | |||||
| T/T | 2 (1.0) | 9 (4.5) | 1 (0.5) | 8 (5.5) | |||||
| rs857403 | |||||||||
| A/A | 124 (59.3) | 138 (68.3) | 0.71 [0.48-1.06] | 0.0909 | 105 (57.1) | 103 (70.5) | 0.62 [0.40-0.97] | 0.0349 | |
| T/A | 75 (35.9) | 56 (27.7) | 70 (38) | 37 (25.3) | |||||
| T/T | 10 (4.8) | 8 (4.0) | 9 (4.9) | 6 (4.1) | |||||
| rs1477017 | |||||||||
| A/A | 100 (47.6) | 81 (40.1) | 1.42 [1.01-2.00] | 0.0415 | 86 (46.5) | 55 (37.7) | 1.51 [1.04-2.20] | 0.0306 | |
| G/A | 91 (43.3) | 98 (48.5) | 82 (44.3) | 72 (49.3) | |||||
| G/G | 19 (9.0) | 23 (11.4) | 17 (9.2) | 19 (13) | |||||
| rs17301608 | |||||||||
| C/C | 94 (45.0) | 75 (37.3) | 1.40 [1.00-1.95] | 0.0510 | 80 (43.5) | 50 (34.5) | 1.47 [1.01-2.12] | 0.0412 | |
| C/T | 94 (45.0) | 100 (49.8) | 85 (46.2) | 73 (50.3) | |||||
| T/T | 21 (10.0) | 26 (12.9) | 19 (10.3) | 22 (15.2) | |||||
| rs1053605 | |||||||||
| C/C | 188 (89.5) | 170 (84.2) | 2.02 [1.09-3.75] | 0.0227 | 166 (89.7) | 127 (87.0) | 1.82 [0.93-3.58] | 0.0817 | |
| C/T | 22 (10.5) | 28 (13.9) | 19 (10.3) | 16 (11.0) | |||||
| T/T | 0 (0.0) | 4 (2.0) | 0 (0.0) | 3 (2.0) | |||||
| rs2241145 | |||||||||
| G/G | 79 (37.8) | 56 (27.9) | 1.66 [1.20-2.30] | 0.0021‡ | 68 (37.0) | 39 (26.9) | 1.67 [1.17-2.40] | 0.0044 | |
| G/C | 100 (47.8) | 101 (50.2) | 88 (47.8) | 72 (49.7) | |||||
| C/C | 30 (14.4) | 44 (21.9) | 28 (15.2) | 34 (23.4) | |||||
| rs243849 | |||||||||
| C/C | 131 (62.7) | 143 (71.5) | 0.70 [0.46-1.07] | 0.0948 | 112 (60.9) | 108 (75) | 0.59 [0.36-0.96] | 0.0314 | |
| T/C | 70 (33.5) | 52 (26.0) | 65 (35.3) | 33 (22.9) | |||||
| T/T | 8 (3.8) | 5 (2.5) | 7 (3.8) | 3 (2.1) | |||||
| rs183112 | |||||||||
| G/G | 134 (64.1) | 145 (72.9) | 0.66 [0.43-1.03] | 0.0669 | 115 (62.5) | 110 (76.9) | 0.54 [0.32-0.90] | 0.0162 | |
| A/G | 70 (33.5) | 51 (25.6) | 65 (35.3) | 32 (22.4) | |||||
| A/A | 5 (2.4) | 3 (1.5) | 4 (2.2) | 1 (0.7) | |||||
| rs1992116 | |||||||||
| G/G | 87 (41.6) | 65 (32.3) | 1.67 [1.20-2.31] | 0.0018‡ | 76 (41.3) | 48 (33.1) | 1.68 [1.17-2.42] | 0.0042 | |
| A/G | 97 (46.4) | 94 (46.8) | 86 (46.7) | 67 (46.2) | |||||
| A/A | 25 (12.0) | 42 (20.9) | 22 (12.0) | 30 (20.7) | |||||
95%CI - 95% Confidence Interval.
*OR [95%CI] and P for the log-additive genetic model after adjustment for significant covariates (history of hypertension, type of stroke, and occurrence of aphasia, paresis, consciousness disturbance and complications during hospitalization).
†OR [95%CI] and P for the log-additive genetic model after adjustment for significant covariates (history of hypertension, and occurrence of aphasia, paresis, consciousness disturbance and complications during hospitalization).
‡Significant result after Bonferroni correction.
Results were adjusted for significant covariates; Odds Ratio (OR)>1 indicates increased probability of poor recovery for the carriers of the minor allele; only associated SNPs are shown.