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. 2010 Apr 8;5(4):e10087. doi: 10.1371/journal.pone.0010087

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Ingold et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Gastric carcinoma samples revealing strong (a) and weak (b) CXCL12 immunoreactivity. Only few cases were CXCL12 negative (c). Note positive CXCL12 staining of blood vessels (arrow). Gastric carcinoma specimens showing a clear cytoplasmic and membranous CXCR4 immunoreactivity were sparse (d). Few samples revealed a weak (e) CXCR4 staining whereas most of the tumours lacked CXCR4 expression (f). Leukocytes served as internal positive control (arrows). Scale bar: a-f: 50 µm.