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. Author manuscript; available in PMC: 2010 Apr 8.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 May 30;49(9):3821–3829. doi: 10.1167/iovs.07-1470

Figure 4.

Figure 4

Morphologic analysis of retinas from 11-month-old albino wild-type (WT) mice on the control diet, abca4−/− mice on the control diet, and abca4−/− mice on the vitamin A (vit A)–supplemented diet. (A–C) Laser confocal images of RPE from the indicated mice showing lipofuscin autofluorescence. (D–F) Electron microscopic images of RPE cells from the indicated mice. Lipofuscin pigment granules are the small, irregularly shaped electron-dense bodies in the RPE cytoplasm. The areas (±SD) of lipofuscin pigment granules divided by total cytoplasmic areas are shown below the electron micrographs. Lipofuscin granules in the wild-type RPE section appear darker because of more intense staining with osmium salts.