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Light micrographs of retinas from 11-month-old albino mice. (A) Wild-type mouse. (B) abca4−/− mouse fed the control diet. (C) abca4−/− mouse fed the vitamin A–supplemented diet. IS, inner segment; INL, inner nuclear layer; ONL, outer nuclear layer. Note the reduced ONL and OS thicknesses in abca4−/− mice, indicating partial photoreceptor degeneration and OS shortening.
