Figure 4.
CPP-mediated suppression of NMDA receptor function in visual cortex and NMDA receptor-dependent ocular dominance plasticity in the critical period. A, Suppression of Zif268 expression in visual cortex at 24 h after CPP injection in juvenile and adult mice. CPP or control saline (Cont) were injected into mice in the critical period at P28 and in adulthood at P80 and the amount of zif268 (top) and β III tubulin (bottom) proteins at 24 h after injection was quantified by immunoblotting. The right panel shows summary data (n = 3 each; *p < 0.05, **p < 0.01). B, Mice in the critical period were treated with CPP 4–6 h before MD on day 0 and every 24 h thereafter and were imaged at 4 d after MD. C, OD shifts after 4 d MD were blocked by daily CPP treatment in critical period mice (n = 3–6; *p < 0.05, **p < 0.01). Data indicated in open circles were taken from Figure 1 for comparison. D, Decrease in the response of the deprived eye after 4 d MD was prevented by daily CPP treatment in critical period mice (n = 3–6). E, Polar maps of cortical responses of critical period mice with or without CPP treatment and MD. Contra, Contralateral; Ipsi, ipsilateral.