Table 1.

Significant rate increases observed with prebinding (s^-1). Fold changes are are of first order fitted rate for the prebinding experiment to the control experiment. Bracketed rates are for datasets that are biphasic according to statistical F-tests (Tables S1–S10), and the resulting fold changes are approximate.

Protein	Experiment	kobs, control	kobs, prebinding	Fold change
S6	1°	[0.030 ± 0.002]	3.6 ± 0.4	120
S10	1°	[0.014 ± 0.002]	[0.045 ± 0.008]	3
S11	1°	[0.032 ± 0.003]	0.32 ± 0.04	10
S13	1°	[0.014 ± 0.003]	[0.06 ± 0.01]	4
S16	1°	[0.81 ± 0.03]	1.4 ± 0.1	1.7
S18	1°	[0.025 ± 0.003]	3.3 ± 0.2	13
S19	1°	0.0188 ± 7.E-04	[0.047 ± 0.003]	2
S5	1° + 2°	9.E-04 ± 6.E+04	0.020 ± 0.002	20
S10	1° + 2°	[0.014 ± 0.002]	[0.96 ± 0.08]	70
S12	1° + 2°	0.003 ± 0.001	0.052 ± 0.003	17
S14	1° + 2°	0.008 ± 0.001	0.048 ± 0.002	6
S3	5′ + c + S7	0.007 ± 0.001	[0.02 ± 0.002]	3
S9	5′ + c + S7	[0.018 ± 0.002]	[0.12 ± 0.01]	7
S10	5′ + c + S7	[0.014 ± 0.002]	[0.023 ± 0.002]	1.6
S14	5′ + c + S7	0.008 ± 0.001	[0.013 ± 0.001]	1.6
S9	S7	[0.018 ± 0.002]	[0.47 ± 0.05]	26
S9	S7 + S13	[0.018 ± 0.002]	[0.082 ± 0.004]	5
S9	S7 + S19	[0.018 ± 0.002]	[4.9 ± 0.2]	300
S10	S7 + S19	[0.014 ± 0.002]	[1.26 ± 0.08]	90
S13	S7 + S19	[0.014 ± 0.003]	[3.1 ± 0.4]	200
S14	S7 + S19	0.008 ± 0.001	0.0121 ± 8.E-04	1.5