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In vivo demonstration of mechanism of action. The beneficial effect of BMSCs on inflammatory changes is eliminated in the presence of TGF-β neutralizing antibodies, but spared when animals are treated with anti-IL-10 antibodies (A and B). BMSCs from TGF-β or STAT6 deficient animals did not induce TGF-β production (C) or decrease BAL total cell numbers (D), eosinophil numbers (E), cytokine levels (F and G), or serum immunoglobulin concentrations (H–J).
