Table 2.

Functional recovery in PEX1-G843D primary fibroblasts cultured in hit chemicals

	Number of importing cells/total cells counted*		Plasmalogen biosynthesis†
Treatment	Thiolase (PTS2)	Catalase (PTS1)	3H/14C (nl < 0.7)
Untreated	46/279 (16%)	47/259 (18%)	1.67 ± 0.34
10 μM acacetin diacetate	54/105 (51%)	69/165 (42%)	0.88 ± 0.12 (P = 0.005)‡
1 μM GF109203x	46/108 (46%)	97/196 (50%)	0.80 ± 0.37 (P = 0.011)
0.5 μM Ro31-8220	48/100 (48%)	52/129 (40%)	0.84 ± 0.32 (P = 0.007)‡
20 μM acacetin			1.16 ± 0.19 (P = 0.04)

*PEX1-214 (G843D/G843D). Experiments were performed in triplicate, and results were pooled.

^†PEX1-643 and PEX1-503 (G843D/G843D). Each cell line was tested in duplicate three times. We report the mean and SD of the pooled treatment results. P value was obtained by unpaired Student t test.

^‡For plasmalogen biosynthesis, we used 20 μM acacetin diacetate and 1 μM Ro31-8220.