Table 1.
Patients from four independent families with chromosome integrated HHV-6
| Family number | Age, sex | Subject | Disease stage | HHV-6 qPCR,* copies per mL | HHV-6 subtype† | Chromosome HHV-6 FISH | Percent sequence identity to HHV-6A (U1102) |
|
| U94 | Direct repeat | |||||||
| 1 | 58, M | Father | Asymptomatic | 629,000 | A | 18q23 | 98% | 98% |
| 1 | 54, F | Mother | PCR negative | Negative | Negative | n/a | n/a | n/a |
| 1 | 24, M | Sibling-1 | Asymptomatic | 1,400,000 | A | 18q23 | 98% | Not done |
| 1 | 22, F | Sibling-2 | CNS dysfunction, hypersomnia | 1,700,000 | A | 18q23 | 98% | Not done |
| 1 | 12, M | Sibling-3 | CNS dysfunction, ataxia | 1,600,000 | A | 18q23 | Not done | Not done |
| 2 | 80, F | Mother | Mild dementia | 625,000 | A | 17p13.3 | 98% | Not done |
| 2 | 45, F | Sibling-1 | CNS dysfunction, fatigue | 4,100,000 | A | 17p13.3 | 98% | 98% |
| 3 | 76, M | Father | Asymptomatic | 2,000,000 | B | 22q13.3 | Not done | Not done |
| 3 | 61, F | Mother | PCR negative | Negative | Negative | n/a | n/a | n/a |
| 3 | 34, M | Sibling-1 | CNS dysfunction, fatigue | 2,000,000 | B | 22q13.3 | Not done | Not done |
| 4 | 62, F | Mother | Asymptomatic | 4,000,000 | B | Not done | Not done | Not done |
| 4 | 36, M | Sibling-1 | Asymptomatic | 4,500,000 | B | Not done | Not done | Not done |
| 4 | 29, F | Sibling-2 | CNS dysfunction, fatigue, ataxia | 4,200,000 | B | Not done | Not done | Not done |
*qPCR on whole blood completed by ViraCor Laboratories (Lee's Summit, MO).
†Subtypes were determined using PCR with subtype-specific primers.