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. 2010 Feb 22;107(12):5681–5686. doi: 10.1073/pnas.0911515107

Fig. 3.

Fig. 3.

Modification of late life socio-environmental mortality risk by rs1800795 genotype. (A) Relationship between depressive symptoms and subsequent all-cause mortality risk for IL6 −174G homozygotes (Right) vs. carriers of one or more C allele (Left). Data represent estimated survival functions from Cox proportional hazards regression analyses controlling for sex and age at study entry (range 70–80 years) in 184 initially healthy Caucasian participants in the MacArthur Study of Successful Aging. Open circles represent mortality risk given cohort average levels of depressive symptoms at study entry (CES-D = 4); filled circles represent mortality risk given high depressive symptoms at study entry (CES-D = 16). (B) Effect of controlling for chronic inflammation (plasma C-reactive protein ≥3 mg/L) on rs1800795 genotype modification of relative mortality hazard associated with low vs. high depressive symptoms at study entry (same cohort of n = 184 MacArthur Study participants as in A). Values represent point estimate (± 95% confidence interval) of relative hazard associated with 75th vs. 25th percentile values of cohort CES-D distribution.