Table 1.

All-cause mortality risk

Model	Depression measure	IL6 −174 genotype	Hazard ratio* (95% CI)	P†
Simple‡	CES-D	CC	0.87 (0.30–2.47)	0.7855
		GC	0.89 (0.57–1.40)	0.6209
		GG	1.76 (1.16–2.68)	0.0079
	SCL-D	CC	1.02 (0.44–2.39)	0.9584
		GC	0.76 (0.43–1.32)	0.3198
		GG	2.13 (1.14–3.95)	0.0166
Adjusted§	CES-D	CC	0.95 (0.25–3.55)	0.9343
		GC	0.76 (0.43–1.33)	0.3331
		GG	2.06 (1.29–3.27)	0.0024
	SCL-D	CC	0.86 (0.19–3.88)	0.8442
		GC	0.52 (0.27–1.01)	0.0521
		GG	7.93 (2.71–23.2)	0.0002

CES-D, Center for Epidemiologic Studies Depression scale; SCL-D, Hopkins’ Symptom Checklist Depression scale.

*Hazard ratio for 75th percentile vs. 25th percentile on depression measure.

^†Two-tailed significance level.

^‡Simple (unadjusted) association between depression and mortality risk.

^§Multivariate analysis controlling for age at study entry, sex, body mass index, smoking, alcohol consumption and socio-economic status.