Table 2.

Inhibition constants for SPX and GYM on ACh-evoked nicotinic currents in oocytes transplanted with muscle-type α1₂βγδ nAChR or expressing the neuronal α4β2 subtype

Ligand	IC50, nM*
	α12βγδ (Torpedo)	α4β2 (Human)
SPX	0.51 (0.4–0.6)	3.9 (2.9–5.1)
GYM	2.8 (1.9–4.1)	0.9 (0.6–1.2)

For further details cf Fig. 2.

*Mean values (95% confidence intervals) from concentration-response curves recorded on 24–36 oocytes for each condition.