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. 2010 Mar 15;107(14):6498–6503. doi: 10.1073/pnas.1001422107

Fig. 2.

Fig. 2.

APα reversed the neurogenic deficits in dentate gyrus of 3-month-old 3xTgAD mice. Stereological estimates of the total number of BrdU-labeled cells in the dentate gyrus of non-Tg and 3xTgAD male mice treated with 1, 10, or 20 mg/kg APα or vehicle alone. (A) Representative immunolabeled BrdU-positive cell images of hippocampal dentate gyrus in APα- or vehicle-treated 3xTgAD mice. (B) A representative image showing magnification at which BrdU-positive cells were analyzed. (C) Summary of dose-dependent effects of APα on BrdU incorporation in non-Tg (Upper) and 3xTgAD (Lower) mice SGZ. Note that 10 mg/kg of APα exerted greatest and statistically significant efficacy. (D) APα reversed the neurogenic deficits within SGZ of the 3xTgAD mouse to restore 3xTgAD mouse proliferation to comparable levels of normal non-Tg mice. Bars represent mean ± SEM, n ≥ 4 in each group, *P < 0.05 vs. vehicle control of the same genotype group.