Table 1.
EC50 of synthetic SP and MIP derivatives on Drosophila SPR expressed in CHO cells
| Name | Sequence | EC50, nM |
| SP | WEWPWNRKPTKFPIPSPNPRDKWCRLNLGPAWGGRC | 2.6 |
| SP12–36 | FPIPSPNPRDKWCRLNLGPAWGGRC | 5.0 |
| SP12–36C36A | FPIPSPNPRDKWCRLNLGPAWGGRA | 161.1 |
| DUP99B | *QDRNDTEWIQSQKDREKWCRLNLGPYLGGRC | 35.7 |
| SP21–36 | DKWCRLNLGPAWGGRC | 6.1 |
| SP21–36, reduced | DKWCRLNLGPAWGGRC | 6.4 |
| SP21–36W23A,C24A,W32A,C36A | DKAARLNLGPAAGGRA | >10,000† |
| SP21–36W23A,W32A | DKACRLNLGPAAGGRC | >10,000† |
| SP21–36C24A,C36A | DKWARLNLGPAWGGRA | 80.2 |
| 16AA3W,A12W | AAWAAAAAAAAWAAAA | >10,000† |
| 16AA3W,A4C,A12W,A16C | AAWCAAAAAAAWAAAC | >10,000† |
| DmMIP1 | AW.QSLQS.SW-a | 0.1 |
| DmMIP1, w/o amidation | AW.QSLQS.SW | 151.9 |
| DmMIP1W2A,W9A | AA.QSLQS.SA-a | >10,000† |
| DmMIP13-8A | AW.AAAAA.AW-a | 12.3 |
†>10,000, no activity at 10 μM concentrations. *Q, underlined P and underlined Cs indicate pyroglutamic acid, hydroxyproline, and disulfide bonds between Cs respectively.