Fig. 1.

Differences and commonalities in gonadal and hippocampal gene expression for Sprague–Dawley rats maintained on low and high energy diets, compared with both healthy “lean” controls and standard ad libitum–fed overweight controls. (A and B) Common and unique significantly altered genes in gonadal tissue (ovaries; A) and hippocampal tissue (B) from rats on 40% caloric restriction, alternate day fasting, and a high fat/glucose diet, compared with standard ad libitum overweight controls and healthy lean controls (20% caloric restriction).