Fig. 2.

Differences and commonalities in gonadal and hippocampal gene ontology (GO) functional groups for Sprague–Dawley rats maintained on low and high energy diets, compared with both healthy “lean” controls and standard ad libitum–fed overweight controls. (A) Common and unique significantly altered GO functional groups in ovaries (A) and hippocampus (B) from rats on 40% caloric restriction, intermittent fasting, and a high fat/glucose diet, compared with standard ad libitum overweight controls and healthy lean controls (20% caloric restriction).