TABLE 2.

PHYSICAL EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF GLIPIZIDE

Form. Code	Surface pH	Thickness (mm)	Swelling Index (2h) Without drug	Swelling Index (2h) With drug	In vitro Residence time (h)	Folding Endurance	Content Uniformity (mg/20 mm diameter of the film)
F1	6.59 ± 0.02	0.28 ± 0.03	40.0 ± 0.3	46.4 ± 0.33	2.25 ± 0.56	164.6 ± 4.53	4.64 ± 0.006
F2	6.50 ± 0.02	0.25 ± 0.03	41.4 ± 1.6	46.8 ± 1.25	3.00 ± 0.72	234.3 ± 12.66	4.66 ± 0.045
F3	6.42 ± 0.03	0.26 ± 0.01	15.9 ± 0.7	17.2 ± 1.16	1.75 ± 0.91	207.7 ± 11.37	4.82 ± 0.014
F4	6.15 ± 0.10	0.26 ± 0.02	29.3 ± 1.0	32.0 ± 0.26	4.00 ± 0.10	290.0 ± 4.0	4.66 ± 0.062

(n = 3) Abbreviations used: HPMC-hydroxypropylmethylcellulose; Sodium CMC-H-Sodium carboxymethylcellulose-high viscosity grade