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ANTIVIRAL ACTIVITY OF ISATIN DERIVATIVE AGAINST SARS-COV IN VERO E6 CELLS
| Compound code | EC50a (μg/ml) | CC50b (μg/ml) | Maximum protection (%) (at 125 μg/ml) |
|---|---|---|---|
| 5CI-IS-AC | >125 | >125 | 0 |
| SPIII-5H | >125 | >125 | 22 |
| SPIII-5Cl | >125 | >125 | 10 |
| SPIII-5Br | >125 | >125 | 2 |
| SPIII-5F | >125 | >125 | 45 |
| SPIII-5Me | >125 | >125 | 12 |
| SPIII-NA | >125 | >125 | 12 |
50% effective concentration required to reduce virus-induced cytopathicity by 50%.
50% cytotoxic concentration required to reduce host cell viability by 50%
